Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fiehler, J. Articles by Kucinski, T. Search for Related Content PubMed PubMed Citation Articles by Fiehler, J. Articles by Kucinski, T.

American Journal of Neuroradiology 26:1056-1061, May 2005
© 2005 American Society of Neuroradiology

BRAIN

Vascular Occlusion Sites Determine Differences in Lesion Growth from Early Apparent Diffusion Coefficient Lesion to Final Infarct

Jens Fiehler^a, Karina Knudsen^a, Götz Thomalla^b, Einar Goebell^a, Michael Rosenkranz^b, Cornelius Weiller^b, Joachim Röther^b, Hermann Zeumer^a and Thomas Kucinski^a

^a Department of Neuroradiology, University Hospital Eppendorf, University of Hamburg, Germany
^b Department of Neurology, University Hospital Eppendorf, University of Hamburg, Germany

Address reprint requests to Jens Fiehler, MD, Department of Neuroradiology, Universitätsklinikum Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany

BACKGROUND AND PURPOSE: Occlusion of major cerebral arteries is the primary source of tissue damage in ischemic stroke and the target of thrombolytic therapy. We hypothesized that large infarcts in more proximal vascular occlusions correspond with substantially increased ischemic lesions shown on initial apparent diffusion coefficient (ADC) maps.

METHODS: Initial ADC lesions in 120 patients with acute ischemic stroke were analyzed within 6 hours of stroke onset. Patients were categorized on the basis of vascular occlusion, as shown on MR angiography. Lesion volumes were determined by using manual delineation (ADC_man) and a threshold method for ADC values (<550 x 10^–9 mm²/s^–1, ADC_<550). Infarct volumes were analyzed by using T2-weighted (n = 109) or CT (n = 11) images obtained on days 5–8.

RESULTS: Median lesion volumes for ADC_<550, ADC_man, and infarcts, respectively, were as follows: proximal internal carotid artery (ICA)/middle cerebral artery (MCA) occlusions, 10, 23, and 32 cm³; carotid-T occlusions, 11, 37, and 138 cm³; MCA trunk occlusions, 11, 27, and 44 cm³); and MCA branch occlusions 8, 27, and 21 cm³. Initial ADC lesion volumes were different only between the carotid T and the MCA branch (P < .05). On days 5–8, infarct volumes decreased from proximal to distal sites (P < .05), with the exception of MCA trunk versus proximal ICA/MCA occlusions. Recanalization rate in carotid-T occlusion was significantly lower than those of all other occlusion types.

CONCLUSION: Initial ADC lesions can be small, even in patients with proximal vascular occlusions. These patients develop considerably large infarctions, suggesting a high potential for infarct growth. This growth might be averted with improved early recanalization of proximal vascular occlusions.

This article has been cited by other articles:

				O. Wu, S. Christensen, N. Hjort, R. M. Dijkhuizen, T. Kucinski, J. Fiehler, G. Thomalla, J. Rother, and L. Ostergaard Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI Brain, September 1, 2006; 129(9): 2384 - 2393. [Abstract] [Full Text] [PDF]

				A. Jaramillo, F. Gongora-Rivera, J. Labreuche, J. -J. Hauw, and P. Amarenco Predictors for malignant middle cerebral artery infarctions: A postmortem analysis Neurology, March 28, 2006; 66(6): 815 - 820. [Abstract] [Full Text] [PDF]