American Journal of Neuroradiology 26:1107-1114, May 2005
© 2005 American Society of Neuroradiology
BRAIN
High Fractional Anisotropy in Brain Abscesses versus Other Cystic Intracranial Lesions
a Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
b Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
c Department of Neurosurgery, King George’s Medical University, Lucknow, India
d Department of Radiology, University of Texas Medical School at Houston, Houston, Texas
Address correspondence to Rakesh K. Gupta, MD, Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, India
BACKGROUND AND PURPOSE: It is known that intracranial mass lesions are relatively isotropic on diffusion-weighted imaging. The purpose of this study is to report an unusually high fractional anisotropy (FA) and mean diffusivity (Dav) in the cavity of the brain abscess compared with other cystic lesions.
METHODS: We performed diffusion tensor imaging (DTI) in 12 patients with cystic intracranial lesions (pyogenic abscess, n = 5; cysticercus cysts, n = 2; and low-grade astrocytoma, n = 5). Mean FA, Dav from the lesion core, perifocal edema, and corresponding contralateral normal-appearing regions were measured and compared for relative changes in these parameters. In the abscess cases, we placed regions of interest on areas with FA >0.2 and FA <0.2 to get FA and Dav values.
RESULTS: There were two patterns of FA values in the abscess cavity in all five patients. Part of the abscess showed mean FA = 0.440 ± 0.135, with Dav = (0.993 ± 0.185) x 10–3 mm2/s, whereas other parts had FA = 0.131 ± 0.039 with Dav = (0.824 ± 0.183) x 10–3 mm2/s. The cystic tumors and neurocysticercosis showed very high Dav = (2.806 ± 0.25, 2.654 ± 0.35)x 10–3 mm2/s, with low FA = (0.108 ± 0.037, 0.08 ± 0.01), respectively.
CONCLUSION: Brain abscess cavity shows regions of increased FA values with restricted mean diffusivity compared with other cystic intracranial lesions. This information may prevent misinterpretation of the DTI information as white matter fiber bundle abnormalities associated with mass lesions.
This article has been cited by other articles:
 |
|
 |
|
  V. Agarwal, M. Kumar, J. K. Singh, R. K. S. Rathore, R. Misra, and R. K. Gupta Diffusion tensor anisotropy magnetic resonance imaging: a new tool to assess synovial inflammation Rheumatology, April 1, 2009; 48(4): 378 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.K. Gupta, K. Nath, A. Prasad, K.N. Prasad, M. Husain, R.K.S. Rathore, N. Husain, C. Srivastava, P. Khetan, R. Trivedi, et al. In Vivo Demonstration of Neuroinflammatory Molecule Expression in Brain Abscess with Diffusion Tensor Imaging AJNR Am. J. Neuroradiol., February 1, 2008; 29(2): 326 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. D. Post A New Era in Neuroradiology: Ex Vivo Validation of In Vivo Imaging Research AJNR Am. J. Neuroradiol., February 1, 2008; 29(2): 212 - 213. [Full Text] [PDF]
|
|
|
|
|
|
R. Trivedi, R.K. Gupta, A. Agarawal, K.M. Hasan, A. Gupta, K.N. Prasad, G. Bayu, D. Rathore, R.K.S. Rathore, and P.A. Narayana Assessment of White Matter Damage in Subacute Sclerosing Panencephalitis Using Quantitative Diffusion Tensor MR Imaging. AJNR Am. J. Neuroradiol., September 1, 2006; 27(8): 1712 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Hasan and J. Provenzale Diffusion Tensor Eigenvalues or Both Mean Diffusivity and Fractional Anisotropy Are Required in Quantitative Clinical Diffusion Tensor MR Reports: Fractional Anisotropy Alone Is Not Sufficient. Radiology, May 1, 2006; 239(2): 611 - 613. [Full Text] [PDF]
|
|