Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Maeda, M. Articles by Takeda, K. Search for Related Content PubMed PubMed Citation Articles by Maeda, M. Articles by Takeda, K.

American Journal of Neuroradiology 26:1186-1192, May 2005
© 2005 American Society of Neuroradiology

HEAD AND NECK

Usefulness of the Apparent Diffusion Coefficient in Line Scan Diffusion-Weighted Imaging for Distinguishing between Squamous Cell Carcinomas and Malignant Lymphomas of the Head and Neck

Masayuki Maeda^a, Hiroya Kato^b, Hajime Sakuma^a, Stephan E. Maier^c and Kan Takeda^a

^a Department of Radiology, Mie University School of Medicine, Japan
^b Department of Pathology, Mie University School of Medicine, Japan
^c Department of Radiology, Brigham and Women’s Hospital, Boston, MA

Address reprint requests to Masayuki Maeda, MD, Department of Radiology, Mie University School of Medicine, 2–174 Edobashi, Tsu, Mie 514-8507, Japan

BACKGROUND AND PURPOSE: Squamous cell carcinoma (SCC) and lymphoma are common malignant tumors of the head and neck. The purpose of this study was to determine whether the apparent diffusion coefficient (ADC) in line scan diffusion-weighted imaging (LSDWI) is useful for distinguishing between SCC and lymphoma of the head and neck.

METHODS: LSDWI was prospectively performed in 39 patients with SCC and in 14 patients with lymphoma. Images were obtained with a diffusion-weighted factor (b factor) of 5 and 1000 s/mm², and ADC maps were generated. ADC values were measured for the two types of tumor.

RESULTS: Mean ADC values were 0.96 ± 0.11 x 10^–3 mm²/s for SCC and 0.65 ± 0.09 x 10^–3 mm²/s for lymphoma; the difference was significant (P < .001). All but one of the patients with lymphoma had ADC values lower than the lowest ADC (0.76 x 10^–3 mm²/s) in patients with SCC. When an ADC of 0.76 x 10^–3 mm²/s was used to distinguish between SCC and lymphoma, accuracy was 98% (52 of 53 lesions).

CONCLUSION: ADC values appear to be useful for distinguishing between SCC and lymphoma in the head and neck.

This article has been cited by other articles:

				A.A.K. A. Razek, A.G. Sadek, O.R. Kombar, T.E. Elmahdy, and N. Nada Role of Apparent Diffusion Coefficient Values in Differentiation Between Malignant and Benign Solitary Thyroid Nodules AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 563 - 568. [Abstract] [Full Text] [PDF]

				H.S. Seo, K.-H. Chang, D.G. Na, B.J. Kwon, and D.H. Lee High b-Value Diffusion (b = 3000 s/mm2) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with b = 1000 s/mm2 AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 458 - 463. [Abstract] [Full Text] [PDF]

				A. Srinivasan, R. Dvorak, K. Perni, S. Rohrer, and S.K. Mukherji Differentiation of Benign and Malignant Pathology in the Head and Neck Using 3T Apparent Diffusion Coefficient Values: Early Experience AJNR Am. J. Neuroradiol., January 1, 2008; 29(1): 40 - 44. [Abstract] [Full Text] [PDF]

				A. D. King, A. T. Ahuja, D. K. W. Yeung, D. K. Y. Fong, Y. Y. P. Lee, K. I. K. Lei, and G. M. K. Tse Malignant Cervical Lymphadenopathy: Diagnostic Accuracy of Diffusion-weighted MR Imaging Radiology, December 1, 2007; 245(3): 806 - 813. [Abstract] [Full Text] [PDF]