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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 26:1583-1586, June-July 2005
© 2005 American Society of Neuroradiology

Case Report
PEDIATRICS

Diffusion Tensor Imaging in Lissencephaly

Nancy Rollins^a,b, Tony Reyes^a and Jon Chia^c

^a Department of Radiology, Children’s Medical Center, Dallas, TX
^b University of Texas Southwestern Medical Center, Dallas, TX
^c Philips Medical Systems, Best, the Netherlands

Address correspondence to Nancy Rollins, MD, Department of Radiology, Children’s Medical Center, 1935 Motor Street, Dallas, TX 75235

Summary: Lissencephaly is a rare brain malformation characterized histologically by arrested neuronal migration such that the brain resembles that of a fetus before 23–24 weeks gestation. We studied a neonate with lissencephaly by using diffusion tensor imaging and suggest the dysplastic densely cellular layer IV is visible as a band of anisotropic diffusion. Fiber tracking showed lack of connectivity between the cortex and deep white matter and an abnormal limbic system.

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