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American Journal of Neuroradiology 26:1690-1694, August 2005
© 2005 American Society of Neuroradiology

Case Report
PEDIATRICS

Brain Apparent Diffusion Coefficient Decrease During Correction of Severe Hypernatremic Dehydration

Andrea Righinia, Luca Ramenghib, Salvatore Zirpolia, Fabio Moscab and Fabio Triulzia

a Departments of Radiology and Neuroradiology, Istituti Clinici di Perfezionamento, Milan, Italy
b Department of Neonatology, Istituti Clinici di Perfezionamento, Milan, Italy

Address correspondence to Andrea Righini, Radiologia e Neuroradiologia, Ospedale Buzzi–ICP, Via Castelvetro 32, 20154 Milan, Italy (e-mail: neurorad{at}icp.mi.it)

Summary: We report on the brain diffusion MR imaging findings in a neonate with severe hypernatremic dehydration, which resulted in cerebral edema (osmotic edema) and in apparent diffusion coefficient decrease, despite a careful and slow rehydration. This report provides in vivo insight into nervous cell response to osmotic challenge.






Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X