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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 26:1932-1936, September 2005
© 2005 American Society of Neuroradiology

Technical Note
INTERVENTIONAL

Modified Histologic Technique for Processing Metallic Coil-Bearing Tissue

Daying Dai^a, Yong Hong Ding^a, Mark A. Danielson^a, Ramanathan Kadirvel^a, Debra A. Lewis^a, Harry J. Cloft^a and David F. Kallmes^a

^a From the Department of Radiology, Mayo Clinic, Rochester, MN

Address correspondence to David F. Kallmes, MD, Department of Radiology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905

We developed a modified paraffin-embedding histologic technique for processing metallic coil-bearing aneurysm tissues. This modified technique was successfully employed for processing platinum coil-bearing tissue for 30 rabbit aneurysms and 6 swine aneurysms. This technique for sectioning coil-bearing aneurysms resulted in little or no tissue distortion and permitted good preservation of morphology and application of multiple advanced staining techniques. This technique is considered beneficial for studying the molecular mechanisms of aneurysm healing after coiling.

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