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American Journal of Neuroradiology 26:1996-1999, September 2005
© 2005 American Society of Neuroradiology

Case Report
BRAIN

Serial MR Imaging Findings of Acute Hemorrhagic Leukoencephalitis: A Case Report

Ho Yun Lee^a, Kee-Hyun Chang^a, Ji Hoon Kim^a, Dong Gyu Na^a, Bae Ju Kwon^a, Kwang-Woo Lee^b and Sung Hye Park^c

^a Department of Radiology and Institute of Radiation Medicine, Seoul, Korea
^b Department of Neurology, Seoul National University College of Medicine, Seoul, Korea
^c Department of Pathology, Seoul National University College of Medicine, Seoul, Korea

Address correspondence to Kee-Hyun Chang, Department of Radiology, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea

Summary: We report a patient with acute hemorrhagic leukoencephalitis with a focus on serial MR imaging findings. Initial MR imaging of a 42-year-old woman revealed a 2.5-cm focal nonhemorrhagic lesion in the left thalamus and internal capsule. Twenty-four days later, fever and altered consciousness developed, and MR imaging showed huge masslike lesions in both frontal lobes, mainly involving the white matter and the genu of the corpus callosum, with massive edematous swelling that contained multifocal small hemorrhages. Most lesions showed high apparent diffusion coefficient value with peripheral small areas of low apparent diffusion coefficient. On follow-up MR imaging obtained 49 days after initial MR imaging, the lesions progressed with increase in extent and development of rim-enhancing necrosis, despite steroid therapy. Following stereotactic biopsy and subsequent high-dose steroid treatment, the patient recovered with some neurologic sequelae. MR imaging obtained at 72 and 126 days revealed residual necrosis and cerebromalacia in the both frontal lobes.

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