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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 26:2108-2113, September 2005
© 2005 American Society of Neuroradiology

HEAD AND NECK

Prediction of Treatment Response in Head and Neck Cancer by Magnetic Resonance Spectroscopy

Tedros Bezabeh^a, Olva Odlum^a,b, Richard Nason^a,c, Paul Kerr^a,c, Donna Sutherland^a,c, Rakesh Patel^a and Ian C.P. Smith^a

^a From the Institute for Biodiagnostics, National Research Council, University of Manitoba, Canada
^b Faculty of Dentistry, University of Manitoba, Canada
^c CancerCare Manitoba, Winnipeg, Manitoba, Canada

Address correspondence to Tedros Bezabeh, PhD, Institute for Biodiagnostics, National Research Council, 435 Ellice Avenue, Winnipeg, Manitoba R3B 1Y6, Canada

BACKGROUND AND PURPOSE: Poor treatment outcome remains high in patients with squamous cell carcinoma (SCC) of the head and neck region. Treatment of head and neck cancer could be improved and perhaps standardized if reliable markers for tumor progression and poor prognosis could be developed. MR spectroscopy has been used previously to differentiate between malignant and adjacent normal specimen in these cancers. This study explores the capability of MR spectroscopy in providing an indication of the aggressiveness of a tumor and its response to treatment.

METHODS: Thirty-six SCC patients with treatment failure, and 22 other patients who were treated concurrently at the same center but with no indication of failure for a period of 3 years, were selected for the study. Tumor specimens were kept frozen at –70°C, and later subjected to ¹H-MR spectroscopy at 25°C. The resonance areas for 6 spectral regions were determined, and their ratio calculated. The mean values of the ratios were then compared between the 2 groups by using the Student t test.

RESULTS: The choline-to-creatine (3.2/3.0 parts per million [ppm]) and the 1.3/0.9 ppm spectral intensity ratios (signal due to lipid or lactic acid) were the 2 most notable ones to be significantly elevated in the group with poor response. Using these ratios, a sensitivity of 83% and a specificity of 82% were obtained in predicting which head and neck cancer patients would fail treatment.

CONCLUSIONS: These preliminary results suggest that MR spectroscopy has the potential to contribute to an accurate and early prediction of tumor behavior and response to treatment in squamous cell carcinoma of the head and neck region.

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