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Case Report
PEDIATRICS

Diffusion Tensor Imaging in Progressive Multifocal Leukoencephalopathy: Early Predictor for Demyelination?

Thierry A.G.M. Huismana, Eugen Boltshauserb, Ernst Martina and David Nadalc

a Department of Diagnostic Imaging ,University Children’s Hospital Zurich, Zurich, Switzerland
b Department of Neurology , University Children’s Hospital Zurich, Zurich, Switzerland
c Department of Infectious Diseases , University Children’s Hospital Zurich, Zurich, Switzerland

Address correspondence to Thierry A.G.M. Huisman, Department of Diagnostic Imaging, University Children’s Hospital Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland

Summary: Progressive multifocal leukoencephalopathy is a severe demyelinating disease of the central nervous system caused by a JC papovavirus infection. Prognosis is poor with fatal outcome within 1 year in 90% of patients. Our case report shows that diffusion tensor imaging can give early and specific information about disease status and extent in a 15-year-old girl with progressive multifocal leukoencephalopathy associated with congenital human immunodeficiency virus (HIV) infection.




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