American Journal of Neuroradiology 26:2153-2156, September 2005
© 2005 American Society of Neuroradiology
Case Report
PEDIATRICS
Diffusion Tensor Imaging in Progressive Multifocal Leukoencephalopathy: Early Predictor for Demyelination?
a Department of Diagnostic Imaging ,University Childrens Hospital Zurich, Zurich, Switzerland
b Department of Neurology , University Childrens Hospital Zurich, Zurich, Switzerland
c Department of Infectious Diseases , University Childrens Hospital Zurich, Zurich, Switzerland
Address correspondence to Thierry A.G.M. Huisman, Department of Diagnostic Imaging, University Childrens Hospital Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland
Summary: Progressive multifocal leukoencephalopathy is a severe demyelinating disease of the central nervous system caused by a JC papovavirus infection. Prognosis is poor with fatal outcome within 1 year in 90% of patients. Our case report shows that diffusion tensor imaging can give early and specific information about disease status and extent in a 15-year-old girl with progressive multifocal leukoencephalopathy associated with congenital human immunodeficiency virus (HIV) infection.
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