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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 26:2178-2182, October 2005
© 2005 American Society of Neuroradiology

Case Report
BRAIN

Brain Compression without Global Neuronal Loss in Meningiomas: Whole-Brain Proton MR Spectroscopy Report of 2 Cases

Benjamin A. Cohen^a, Edmond A. Knopp^a,b, Henry Rusinek^a, Songtao Liu^a and Oded Gonen^a

^a Department of Radiology, New York University School of Medicine, New York, NY
^b Department of Neurosurgery, New York University School of Medicine, New York, NY

Address correspondence to Edmond A. Knopp, MD, Department of Radiology New York University School of Medicine, 550 First Avenue New York, NY 10016

Summary: We report the findings from whole-brain proton MR spectroscopy, quantifying the neuronal marker N-acetylaspartate (NAA), for 2 presurgical meningioma patients and 10 healthy controls. The patients’ whole-brain NAA (WBNAA) concentrations were considerably elevated (3+ SDs) compared with healthy controls when excluding the tumors from brain volume; WBNAA levels normalized following correction to approximate "preneoplastic" brain size. These results suggest global neuronal preservation in these 2 patients while their brains were compressed by large, slowly growing, extra-axial masses.

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