American Journal of Neuroradiology 26:2183-2186, October 2005
© 2005 American Society of Neuroradiology
Technical Note
BRAIN
Fiber Density Index Correlates with Reduced Fractional Anisotropy in White Matter of Patients with Glioblastoma
a From the Department of Medical Imaging, University of Toronto, Toronto, Canada
b Department of Radiology, Johns Hopkins University, Baltimore, MD
Address correspondence to Tim P.L. Roberts, PhD, Department of Radiology, Children’s Hospital of Philadelphia, Wood Bldg., Suite 2115, 34th St. and Civic Center Blvd., Philadelphia, PA 19104
Summary: A quantitative description of white matter fiber attenuation, the fiber density index (FDi) is described. This measure is derived from quantitative analysis of diffusion tensor imaging and reveals an index of the number of fiber paths traversing a region of interest. In this report, FDi is computed in 10 patients with glioblastoma multiforme, in white matter that is peritumoral and contralateral. FDi is shown to correlate significantly with fractional anisotropy.
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