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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 26:2213-2217, October 2005
© 2005 American Society of Neuroradiology

Technical Note
BRAIN

Prediction of Hemorrhage in Acute Ischemic Stroke Using Permeability MR Imaging

Andrea Kassner^a, Timothy Roberts^a, Keri Taylor^b, Frank Silver^c and David Mikulis^b

^a Department of Medical Imaging, University of Toronto & UHN (Princess Margaret Hospital), Toronto, Ontario, Canada
^b Department of Medical Imaging, The Toronto Western Hospital, Toronto, Ontario, Canada
^c Department of Neurology, The Toronto Western Hospital, Toronto, Ontario, Canada

Address correspondence to Andrea Kassner, PhD, Department of Medical Imaging, UHN Princess Margaret Hospital, Room 3-975, 610 University Ave., Toronto, Ontario M5S 2M9, Canada

Summary: Increased risk of hemorrhagic transformation (HT) limits the general use of thrombolytic therapy in acute ischemic stroke (AIS). This study shows that early blood-brain barrier defects in AIS can be assessed by using permeability MR imaging. Significantly increased permeability was found in 3 patients who later hemorrhaged. This method indicates the potential for identifying patients at higher risk of HT and offers the use of physiologic imaging rather than time from onset of symptoms to guide treatment decisions.

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