American Journal of Neuroradiology 26:2213-2217, October 2005
© 2005 American Society of Neuroradiology
Technical Note
BRAIN
Prediction of Hemorrhage in Acute Ischemic Stroke Using Permeability MR Imaging
a Department of Medical Imaging, University of Toronto & UHN (Princess Margaret Hospital), Toronto, Ontario, Canada
b Department of Medical Imaging, The Toronto Western Hospital, Toronto, Ontario, Canada
c Department of Neurology, The Toronto Western Hospital, Toronto, Ontario, Canada
Address correspondence to Andrea Kassner, PhD, Department of Medical Imaging, UHN Princess Margaret Hospital, Room 3-975, 610 University Ave., Toronto, Ontario M5S 2M9, Canada
Summary: Increased risk of hemorrhagic transformation (HT) limits the general use of thrombolytic therapy in acute ischemic stroke (AIS). This study shows that early blood-brain barrier defects in AIS can be assessed by using permeability MR imaging. Significantly increased permeability was found in 3 patients who later hemorrhaged. This method indicates the potential for identifying patients at higher risk of HT and offers the use of physiologic imaging rather than time from onset of symptoms to guide treatment decisions.
This article has been cited by other articles:
 |
|
 |
|
  A. Kassner, T.P.L. Roberts, B. Moran, F.L. Silver, and D.J. Mikulis Recombinant Tissue Plasminogen Activator Increases Blood-Brain Barrier Disruption in Acute Ischemic Stroke: An MR Imaging Permeability Study AJNR Am. J. Neuroradiol., November 1, 2009; 30(10): 1864 - 1869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hom, J.W. Dankbaar, T. Schneider, S.-C. Cheng, J. Bredno, and M. Wintermark Optimal Duration of Acquisition for Dynamic Perfusion CT Assessment of Blood-Brain Barrier Permeability Using the Patlak Model AJNR Am. J. Neuroradiol., August 1, 2009; 30(7): 1366 - 1370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.A. Konstas, G.V. Goldmakher, T.-Y. Lee, and M.H. Lev Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 2: Technical Implementations AJNR Am. J. Neuroradiol., May 1, 2009; 30(5): 885 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. I. Aviv, C. D. d'Esterre, B. D. Murphy, J. J. Hopyan, B. Buck, G. Mallia, V. Li, L. Zhang, S. P. Symons, and T.-Y. Lee Hemorrhagic Transformation of Ischemic Stroke: Prediction with CT Perfusion Radiology, March 1, 2009; 250(3): 867 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Y. Bang, J. L. Saver, J. R. Alger, S. H. Shah, B. H. Buck, S. Starkman, B. Ovbiagele, D. S. Liebeskind, and for the UCLA MRI Permeability Investigators Patterns and Predictors of Blood-Brain Barrier Permeability Derangements in Acute Ischemic Stroke Stroke, February 1, 2009; 40(2): 454 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Derex and N Nighoghossian Intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: an update J. Neurol. Neurosurg. Psychiatry, October 1, 2008; 79(10): 1093 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Foerch, M. T. Wunderlich, F. Dvorak, M. Humpich, T. Kahles, M. Goertler, J. Alvarez-Sabin, C. W. Wallesch, C. A. Molina, H. Steinmetz, et al. Elevated Serum S100B Levels Indicate a Higher Risk of Hemorrhagic Transformation After Thrombolytic Therapy in Acute Stroke Stroke, September 1, 2007; 38(9): 2491 - 2495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lin, K.S. Kazmi, M. Law, J. Babb, N. Peccerelli, and B.K. Pramanik Measuring Elevated Microvascular Permeability and Predicting Hemorrhagic Transformation in Acute Ischemic Stroke Using First-Pass Dynamic Perfusion CT Imaging AJNR Am. J. Neuroradiol., August 1, 2007; 28(7): 1292 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Khatri, L. R. Wechsler, and J. P. Broderick Intracranial Hemorrhage Associated With Revascularization Therapies Stroke, February 1, 2007; 38(2): 431 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Srinivasan, M. Goyal, F. A. Azri, and C. Lum State-of-the-Art Imaging of Acute Stroke RadioGraphics, October 1, 2006; 26(suppl_1): S75 - S95. [Abstract] [Full Text] [PDF]
|
|