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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 26:2316-2319, October 2005
© 2005 American Society of Neuroradiology

Case Report
BRAIN

Prominent Perivenular Spaces in Multiple Sclerosis as a Sign of Perivascular Inflammation in Primary Demyelination

Yulin Ge^a, Meng Law^a, Joseph Herbert^b and Robert I. Grossman^a

^a Department of Radiology, New York University School of Medicine, New York, NY
^b Department of Neurology, Hospital for Joint Disease, New York University School of Medicine, New York, NY

Address correspondence to Yulin Ge, MD, Department of Radiology, New York University Medical Center, 560 First Avenue, OBH-D-120 (C&D Bldg.), New York, NY 10016

Summary: In this study, we describe prominent perivenular spaces as a sign that is seen on high-resolution (512 x 512) transverse T2-weighted MR images in patients with multiple sclerosis. The observed widening of perivenular space is depicted as a stringlike hyperintensity projecting radially and aligned with multiple sclerosis lesions (usually small), following the course and configuration of deep venular structures. This widening may be an important sign in differentiating primary (ie, in multiple sclerosis) from secondary causes of demyelination.

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