Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jou, L.-D. Articles by Saloner, D. Search for Related Content PubMed PubMed Citation Articles by Jou, L.-D. Articles by Saloner, D.

American Journal of Neuroradiology 26:2357-2363, October 2005
© 2005 American Society of Neuroradiology

INTERVENTIONAL

Correlation between Lumenal Geometry Changes and Hemodynamics in Fusiform Intracranial Aneurysms

Liang-Der Jou^a, Gregory Wong^a, Brad Dispensa^c, Michael T. Lawton^b, Randall T. Higashida^a,b,c,d, William L. Young^b,c,d and David Saloner^a

^a Department of Radiology, University of California–San Francisco, San Francisco, CA
^b Department of Neurological Surgery, University of California–San Francisco, San Francisco, CA
^c Department of Anesthesia and Perioperative Care, University of California–San Francisco, San Francisco, CA
^d Department of Neurology, University of California–San Francisco, San Francisco, CA

Address correspondence to Liang-Der Jou, PhD, McGowan Institute for Regenerative Medicine and Department of Radiology and Bioengineering, University of Pittsburgh, 3025 E. Carson St., Pittsburgh, PA 15203

BACKGROUND AND PURPOSE: Hemodynamics may predispose aneurysms to rupture; however, hemodynamic descriptors that can describe aneurysm growth are not well understood. We examined the relationship between hemodynamics and growth of 2 fusiform basilar artery aneurysms in an effort to define hemodynamic variables that may be helpful in predicting aneurysmal growth.

METHODS: Two patients with basilar fusiform aneurysms of a similar size were followed for a 2-year period. The lumenal geometry and inflow and outflow rates were acquired by using MR angiography and velocimetry, respectively. The location of aneurysmal growth was identified by coregistering aneurysm models that were acquired at different times. Hemodynamic descriptors were calculated by using computational fluid dynamic simulations and compared with aneurysm growth pattern.

RESULTS: One patient had an aneurysm that grew significantly, but a similar-sized aneurysm in the other patient remained unchanged. The largest aneurysmal growth (3 mm/year) was found at the inferior side (lower part) of the aneurysm, where the wall shear stress was very low (<0.1N/m²). The general flow patterns did not change with time, even in the aneurysm that grew, but histograms of wall shear stress were very different in these 2 patients.

CONCLUSIONS: This study investigates whether hemodynamic descriptors can be correlated with regional changes in aneurysm lumen morphology on a patient-specific basis. That capability will permit the testing, in longitudinal studies, of hypotheses as to which mechanisms are the most important in aneurysm growth.

This article has been cited by other articles:

				Z. Touat, L. Lepage, V. Ollivier, P. Nataf, U. Hvass, J. Labreuche, M. Jandrot-Perrus, J.-B. Michel, and G. Jondeau Dilation-Dependent Activation of Platelets and Prothrombin in Human Thoracic Ascending Aortic Aneurysm Arterioscler. Thromb. Vasc. Biol., May 1, 2008; 28(5): 940 - 946. [Abstract] [Full Text] [PDF]

				L. Boussel, M. Wintermark, A. Martin, B. Dispensa, R. VanTijen, J. Leach, V. Rayz, G. Acevedo-Bolton, M. Lawton, R. Higashida, et al. Monitoring Serial Change in the Lumen and Outer Wall of Vertebrobasilar Aneurysms AJNR Am. J. Neuroradiol., February 1, 2008; 29(2): 259 - 264. [Abstract] [Full Text] [PDF]