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American Journal of Neuroradiology 26:2364-2367, October 2005
© 2005 American Society of Neuroradiology

INTERVENTIONAL

Can Neck Size in Elastase-Induced Aneurysms Be Controlled? A Prospective Study

Yong Hong Ding, Daying Dai, Debra A. Lewis, Mark A. Danielson, Ramanathan Kadirvel, Jayawant N. Mandrekar, Harry J. Cloft and David F. Kallmes

Departments of Radiology and Health Sciences Research Division of Biostatistics, Mayo Clinic, Rochester, MN

Address correspondence to David F. Kallmes, MD, Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905

BACKGROUND AND PURPOSE: An earlier retrospective study indicated that the neck size of elastase-induced aneurysms could be controlled by adjusting the position of the inflated balloon. We report the current prospective study to confirm our previous work.

METHODS: Ninety elastase-induced aneurysms were created in rabbits. Group 1 (n = 62) included cases in which the occlusion balloon resided low, completely within the brachiocephalic/subclavian arteries. Group 2 (n = 28) included cases in which the balloon resided high, within both the common carotid artery and brachiocephalic/subclavian arteries. Follow-up digital subtraction angiography was performed. The aneurysm sizes were measured and compared between groups. The Student t test and the Fisher exact test were used for statistical analysis.

RESULTS: The mean aneurysm neck diameter and width for group 1 was significantly larger than that of group 2 (3.4 ± 1.2 and 2.3 ± 0.9 mm, P < .001; 3.8 ± 1.0 and 3.3 ± 0.9 mm, P < .05, respectively). The proportion of wide-necked aneurysms in group 1 was significantly larger than that in group 2 (29% vs 4%; P < .005). Mean dome-to-neck ratios were 1.2 ± 0.4 and 1.7 ± 0.7 for groups 1 and 2 (P < .005). There was no significant difference in aneurysm height between groups 1 and 2 (8.0 ± 1.7 and 7.5 ± 2.2 mm; P > .05).

CONCLUSION: The neck size of elastase-induced aneurysm models in rabbits can be controlled by adjusting the position of the inflated balloon.




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