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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:200-203, January 2006
© 2006 American Society of Neuroradiology

CASE REPORT
PEDIATRICS

Leukoencephalopathy, Cerebral Calcifications, and Cysts

U. Sener^a, Y. Zorlu^a, S. Men^c, U. Bayol^b and U. Zanapalioglu^a

^a Department of Neurology, SSK Tepecik Teaching Hospital, Izmir, Turkey
^b Department of Pathology, SSK Tepecik Teaching Hospital, Izmir, Turkey
^c Department of Radiology, Dokuz Eylul University, Izmir, Turkey

Address correspondence to: Ufuk Sener, MD, 294 sok. No. 1/3, Yagizer, Apartment 35350, Guzelyali, Izmir, Turkey

SUMMARY: Association of leukoencephalopathy, cerebral calcifications, and cysts (LCC) is a rare disorder that was recently described. To our knowledge, only 2 reports, including 3 patients in each, have been published in the literature to date. Herein, we report a 19-year-old man with LCC who had neurological symptoms beginning in late adolescence. Clinically, he had rare convulsive seizures, slowly progressive pyramidal symptoms, and normal intelligence. On radiological examination, there were progressive calcifications in the basal nuclei and the cerebral white matter, as well as parenchymal cysts and diffuse abnormal signals of the white matter on T2-weighted sequences on MR imaging. On histopathological examination, angiomatous changes and secondary gliosis were demonstrated.

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				I Wargon, M-C Lacour, D Adams, and C Denier A small deep infarct revealing leukoencephalopathy, calcifications and cysts in an adult patient J. Neurol. Neurosurg. Psychiatry, February 1, 2008; 79(2): 224 - 225. [Full Text] [PDF]