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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:2112-2114, November-December 2006
© 2006 American Society of Neuroradiology

Case Report
SPINE

Copper Deficiency Myeloneuropathy Resembling B₁₂ Deficiency: Partial Resolution of MR Imaging Findings with Copper Supplementation

B.P. Goodman^a, B.W. Chong^b, A.C. Patel^b, G.P. Fletcher^b and B.E. Smith^a

^a Department of Neurology, Mayo Clinic Scottsdale, Scottsdale, Ariz
^b Department of Radiology, Mayo Clinic Scottsdale, Scottsdale, Ariz

Please address correspondence to Brent P. Goodman, MD, Department of Neurology, Mayo Clinic Scottsdale, 13400 East Shea Blvd, Scottsdale, AZ 85259; e-mail: goodman.brent{at}mayo.edu

SUMMARY: Copper deficiency has been associated with a clinical syndrome, myeloneuropathy. Radiographic changes resembling B₁₂ deficiency in the cervical spinal cord have been described. We present a case of copper deficiency myeloneuropathy, with cervical MR imaging findings resembling B₁₂ deficiency, which partially reversed following copper supplementation. This is, to our knowledge, the first described case of radiographic improvement with copper supplementation.

This article has been cited by other articles:

				B P Goodman, E P Bosch, M A Ross, C Hoffman-Snyder, D D Dodick, and B E Smith Clinical and electrodiagnostic findings in copper deficiency myeloneuropathy J. Neurol. Neurosurg. Psychiatry, May 1, 2009; 80(5): 524 - 527. [Abstract] [Full Text] [PDF]