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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:2115-2117, November-December 2006
© 2006 American Society of Neuroradiology

Case Report
SPINE

A Multiparametric Brain and Cord MR Imaging Study of a Patient with Hirayama Disease

A. Gallo^a,b, M.A. Rocca^a, P. Tortorella^a, A. Ammendola^c, G. Tedeschi^b and M. Filippi^a

^a Neuroimaging Research Unit, Department. of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
^b II Department of Neurology, Second University of Naples, Naples, Italy
^c Department of Neurophysiopathology, Second University of Naples, Naples, Italy

Please address correspondence to Massimo Filippi, MD, Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy; e-mail address: massimo.filippi{at}hsr.it

SUMMARY: In this study, we used a multiparametric MR imaging approach to assess a patient with Hirayama disease (HD). We found that cervical cord damage extends beyond cord T2-visible lesions. We also showed an altered pattern of cortical activations during movements of clinically unaffected limbs. Whereas this study suggests a more widespread cord involvement in HD than seen on routine MR imaging, its cause remains unclear (vascular damage versus a primary lower motor neuron disease).