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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:2149-2154, November-December 2006
© 2006 American Society of Neuroradiology

BRAIN

Predictive Value of Hippocampal MR Imaging-Based High-Dimensional Mapping in Mesial Temporal Epilepsy: Preliminary Findings

R.E. Hogan^a, L. Wang^d, M.E. Bertrand^a, L.J. Willmore^a, R.D. Bucholz^b, A.S. Nassif^c and J.G. Csernansky^d

^a Department of Neurology, Saint Louis University, St. Louis, Mo
^b Department of Surgery, Saint Louis University, St. Louis, Mo
^c Department of Radiology, Saint Louis University, St. Louis, Mo
^d Department of Psychiatry, Washington University School of Medicine, St. Louis, Mo

Address correspondence to R. Edward Hogan, MD, Department of Neurology, Washington University in St. Louis, Campus Box 8111, 660 S. Euclid Ave, St. Louis, MO 63110-1093; e-mail: hogane{at}neuro.wustl.edu

BACKGROUND AND PURPOSE:We objectively assessed surface structural changes of the hippocampus in mesial temporal sclerosis (MTS) and assessed the ability of large-deformation high-dimensional mapping (HDM-LD) to demonstrate hippocampal surface symmetry and predict group classification of MTS in right and left MTS groups compared with control subjects.

METHODS:Using eigenvector field analysis of HDM-LD segmentations of the hippocampus, we compared the symmetry of changes in the right and left MTS groups with a group of 15 matched controls. To assess the ability of HDM-LD to predict group classification, eigenvectors were selected by a logistic regression procedure when comparing the MTS group with control subjects.

RESULTS:Multivariate analysis of variance on the coefficients from the first 9 eigenvectors accounted for 75% of the total variance between groups. The first 3 eigenvectors showed the largest differences between the control group and each of the MTS groups, but with eigenvector 2 showing the greatest difference in the MTS groups. Reconstruction of the hippocampal deformation vector fields due solely to eigenvector 2 shows symmetrical patterns in the right and left MTS groups. A "leave-one-out" (jackknife) procedure correctly predicted group classification in 14 of 15 (93.3%) left MTS subjects and all 15 right MTS subjects.

CONCLUSION:Analysis of principal dimensions of hippocampal shape change suggests that MTS, after accounting for normal right-left asymmetries, affects the right and left hippocampal surface structure very symmetrically. Preliminary analysis using HDM-LD shows it can predict group classification of MTS and control hippocampi in this well-defined population of patients with MTS and mesial temporal lobe epilepsy (MTLE).

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				S.R. Dager, L. Wang, S.D. Friedman, D.W. Shaw, J.N. Constantino, A.A. Artru, G. Dawson, and J.G. Csernansky Shape Mapping of the Hippocampus in Young Children with Autism Spectrum Disorder AJNR Am. J. Neuroradiol., April 1, 2007; 28(4): 672 - 677. [Abstract] [Full Text] [PDF]