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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:2199-2201, November-December 2006
© 2006 American Society of Neuroradiology

Case Report
HEAD & NECK

Metachronous, Multicentric Giant Cell Tumor of the Sphenoid Bone with Histologic, CT, MR Imaging, and Positron-Emission Tomography/CT Correlation

A.M. McKinney^a, P. Reichert^a, J. Short^a, T. Dhurairaj^a, K. SantaCruz^a, Z. McKinney^a and S. Kieffer^a

^a From the Department of Radiology, University of Minnesota Medical School and Hennepin County Medical Center, Minneapolis, Minn

Please address correspondence to: Alexander McKinney, MD, Hennepin County Medical Center, Department of Radiology, 701 Park Ave South, Minneapolis, MN 55415; e-mail: mckin022{at}umn.edu

SUMMARY: Giant cell tumor (GCT) of the sphenoid bone is a relatively rare entity and metachronous multicentric GCT of the sphenoid is even rarer; we are aware of only 3 previous cases in the literature. We describe here a tumor of the sphenoid bone that was identified 15 years after multiple resections of a GCT of the left inferior pubic ramus. Correlation is made between the histopathologic findings, MR imaging of the brain, CT of the head, and fusion positron-emission tomography (PET)/CT scan performed with fluorine-18 fluoro-2-deoxy-D-glucose (18F-FDG). This report is the first to describe the appearance of a GCT of the sphenoid bone on a fusion PET/CT examination. High metabolic activity in the base of the skull adjacent to the middle cranial fossa was demonstrated in a fashion similar to that of the known pelvic lesion. This case also demonstrates that the increased metabolic activity seen in a GCT of the sphenoid bone may be partially obscured by the adjacent physiologic high metabolic activity of the brain.

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