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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:620-623, March 2006
© 2006 American Society of Neuroradiology

Case Report
BRAIN

Reversible Cytotoxic Cerebral Edema in Cerebral Fat Embolism

D.J.A. Butteriss^a, D. Mahad^b, C. Soh^a, T. Walls^b, D. Weir^c and D. Birchall^a

^a Department of Neuroradiology, Newcastle General Hospital, Newcastle-upon-Tyne, Tyne and Wear, United Kingdom
^b Department of Neurology, Newcastle General Hospital, Newcastle-upon-Tyne, Tyne and Wear, United Kingdom
^c Department of Orthopaedic Surgery, Newcastle General Hospital, Newcastle-upon-Tyne, Tyne and Wear, United Kingdom

Address correspondence to Daniel Birchall, MD, Consultant Neuroradiologist, Department of Neuroradiology, Newcastle General Hospital, Westgate Rd, Newcastle-upon-Tyne, Tyne and Wear NE1 1SA, United Kingdom

SUMMARY: We present a case of cerebral fat embolism (CFE) that demonstrated evidence of diffuse white matter cytotoxic edema on diffusion-weighted magnetic resonance imaging, in addition to punctate hyperintensities on T2-weighted and diffusion-weighted imaging. The case suggests that CFE represents a combination of occlusive arteriolar disease and secondary neurotoxicity.