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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:806-809, April 2006
© 2006 American Society of Neuroradiology

Case Report
PEDIATRICS

Longitudinal MR Spectroscopic Imaging of Pediatric Diffuse Pontine Tumors to Assess Tumor Aggression and Progression

S.B. Thakur^a, S. Karimi^b, I.J. Dunkel^c, J.A. Koutcher^a,b,d and W. Huang^a,b

^a Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY
^b Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY
^c Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY
^d Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY

Address correspondence to Wei Huang, PhD, Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021

SUMMARY: Two pediatric patients with diffuse pontine tumors underwent MR spectroscopic imaging pre- and postradiation. Choline/creatine (Cho/Cr) and Cho/N-acetylaspartate (NAA) ratios were elevated before treatment, with no MR imaging contrast enhancement. These ratios were further elevated at 2 posttreatment follow-up studies, despite signs of excellent clinical improvement at initial follow-up. This study suggests that MR spectroscopic imaging is more specific in assessing the aggressiveness of diffuse pontine tumors than conventional MR imaging and can serve as a valuable tool in early prognostication.

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