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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:836-838, April 2006
© 2006 American Society of Neuroradiology

Case Report
BRAIN

Widening Spectrum of a Reversible Splenial Lesion with Transiently Reduced Diffusion

J. Takanashi^a, A.J. Barkovich^g, T. Shiihara^b, H. Tada^c, M. Kawatani^d, H. Tsukahara^d, M. Kikuchi^e and M. Maeda^f

^a Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan
^b Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan
^c Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan
^d Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
^e Division of Pediatrics, Hitachi General Hospital, Hitachi, Japan
^f Department of Radiology, Mie University School of Medicine, Mie, Japan
^g Neuroradiology Section, Department of Radiology, University of California San Francisco, Calif

Address correspondence to Jun-ichi Takanashi, MD, Department of Pediatrics, Kameda Medical Center, 929 Higashi-cho, Kamogawa-shi, Chiba 296-8602, Japan

SUMMARY: Four patients with encephalitis/encephalopathy and parenchymal lesions accompanying reversible splenial lesions were retrospectively evaluated. In 3 patients, reversible lesions with transiently reduced diffusion were seen in the splenium and symmetrically in the peripheral frontoparietal white matter, clinical signs and symptoms were mild, and recovery was complete. These and previous observations suggest a less severe course and outcome for patients with reversible lesions isolated to the splenium or to the splenium and peripheral frontoparietal white matter.

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