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American Journal of Neuroradiology 27:879-881, April 2006
© 2006 American Society of Neuroradiology

Case Report
BRAIN

Corpus Callosum Diffusion Anisotropy Correlates with Neuropsychological Outcomes in Twins Disconcordant for Traumatic Brain Injury

L. Ewing-Cobbsa, K.M. Hasanb, M.R. Prasada, L. Kramerb and J. Bachevalierc

a Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Tex
b Department of Interventional and Diagnostic Imaging, University of Texas Health Science Center at Houston, Houston, Tex
c Department of Psychology, Emory University, Atlanta, Ga

Address correspondence to: Linda Ewing-Cobbs, PhD, Department of Pediatrics, University of Texas-Houston Health Science Center, 7000 Fannin–UCT 2401, Houston, TX 77030

SUMMARY: Conventional and diffusion tensor MR imaging studies in twins sustaining severe pediatric traumatic brain injury identified reduction in fractional anisotropy (FA) in all regions of the corpus callosum, particularly the posterior body, rostral body, and genu, relative to healthy cotwins. FA from the rostrum, genu, anterior body, posterior body, and isthmus were correlated with measures of reading speed and comprehension; verbal working memory and math fact retrieval scores were correlated only with the rostral body FA.




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Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X