Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lange, T. Articles by Boesiger, P. Search for Related Content PubMed PubMed Citation Articles by Lange, T. Articles by Boesiger, P.

American Journal of Neuroradiology 27:895-901, April 2006
© 2006 American Society of Neuroradiology

Technical Note
BRAIN

Pitfalls in Lactate Measurements at 3T

T. Lange^a, U. Dydak^a, T.P.L. Roberts^b, H.A. Rowley^c, M. Bjeljac^d and P. Boesiger^a

^a Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
^b Radiology Department, Children’s Hospital of Philadelphia, Philadelphia, Pa
^c Radiology Department, University of Wisconsin, Madison, Wisc
^d Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland

Address correspondence to Peter Boesiger, PhD, Institute for Biomedical Engineering, University and ETH Zurich, Gloriastr 35, CH-8092 Zurich, Switzerland

SUMMARY: In clinical MR spectroscopy at higher field strengths, lactate may show reduced or absent signal intensity at an echo time of 144 ms. Although this false-negative result may be predicted from theory, experimental verification and clinical impact have not been fully established. Using scanners from 3 major vendors, spectra from phantoms and patients demonstrate the lactate signal loss and potential error in interpretation. Strategies are discussed to overcome, or at least alleviate, this problem.

This article has been cited by other articles:

				H.-S. Liu, H.-W. Chung, C.-J. Juan, S.-Y. Tsai, C.-Y. Wang, C.-C. Chan, G.-S. Huang, M.-C. Chou, C.-S. Lee, C.-W. Ko, et al. Anomalous J-Modulation Effects on Amino Acids in Clinical 3T MR Spectroscopy AJNR Am. J. Neuroradiol., October 1, 2008; 29(9): 1644 - 1648. [Abstract] [Full Text] [PDF]

				T. Bartsch, K. Alfke, S. Wolff, A. Rohr, O. Jansen, and G. Deuschl Focal MR spectroscopy of hippocampal CA-1 lesions in transient global amnesia Neurology, March 25, 2008; 70(13): 1030 - 1035. [Abstract] [Full Text] [PDF]