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American Journal of Neuroradiology 27:1016-1018, May 2006
© 2006 American Society of Neuroradiology

Case Report
BRAIN

MR Imaging of BK Virus Encephalitis

D.P. Friedman and A.E. Flanders

From the Department of Radiology, Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, Pa

Address correspondence to David P. Friedman, Department of Radiology, Jefferson Medical College and Thomas Jefferson University Hospital, 132 South 10th St, Suite 1072, Main Building, Philadelphia, PA 19107

SUMMARY: BK virus infection is most often associated with urologic disease in patients who have undergone renal or bone marrow transplantation. We report a rare case of biopsy-confirmed BK virus encephalitis in an immunocompromised patient with hemorrhagic cystitis, in whom dramatic imaging findings were present despite relatively mild clinical symptoms. MR imaging demonstrated widespread increased signal intensity on T2- and fluid-attenuated inversion recovery–weighted images, with restricted diffusion, in the cerebellum, cerebral white matter, and deep gray matter structures. The simultaneous presence of urologic abnormalities and neurologic deficits in certain immunocompromised patients should prompt consideration of BK virus encephalitis.






Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X