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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:1096-1097, May 2006
© 2006 American Society of Neuroradiology

Case Report
HEAD AND NECK

Bisphosphonate-Associated Mandibular Osteonecrosis

E. Carneiro^a, P. Vibhute^b, A. Montazem^c and P.M. Som^b

^a Department of Neuroradiology, Sao Joao Hospital, Porto, Portugal
^b Departments of Radiology, Mount Sinai School of Medicine of New York University, New York, NY
^c Departments of Dentistry, Mount Sinai School of Medicine of New York University, New York, NY

Address correspondence to Peter M. Som, MD, Department of Radiology, Mount Sinai Hospital, One Gustave Levy Place, New York, NY 10029

SUMMARY: A 66-year-old man with multiple myeloma treated with zoledronic acid, melphalan, and prednisone after a tooth extraction developed severe osteonecrosis of the mandible that was nonresponsive to antibiotic therapy. A CT scan showed innumerable fragmented sequestra in the mandible and some adjacent soft tissue fullness around the mandible. The association between the use of bisphosphonates and osteonecrosis of the jaw has been described only recently.

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