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American Journal of Neuroradiology 27:958-961, May 2006
© 2006 American Society of Neuroradiology

PATHOLOGY REVIEW

Neuropathology for the Neuroradiologist: Rosenthal Fibers

F.J. Wippold, IIa,b,c, A. Perryd,e and J. Lennerzd,e

a From the Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Mo
b Department of Radiology, Barnes-Jewish Hospital South, St. Louis, Mo
c Department of Radiology/Nuclear Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md
d F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md
e Neuropathology Division, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Mo

Address correspondence to Franz J. Wippold, II, MD, Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University Medical Center, 510 South Kingshighway Blvd., St. Louis, MO 63110

SUMMARY: Distinctive intracellular structures known as inclusions may be occasionally observed on stained tissue preparations and may further suggest a specific diagnosis. Pathologists rely on these findings much as radiologists rely on findings revealed in the gray-scale patterns of densities and intensities on images. Appreciation of these inclusions can enhance the interactions of the neuroradiologist with the neuropathologist and deepen understanding of certain conditions. This report reviews the neuropathologically observed intracellular inclusions known as Rosenthal fibers in the context of Alexander disease and slow-growing tumors such as pilocytic astrocytoma.




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Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X