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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:1239-1240, June-July 2006
© 2006 American Society of Neuroradiology

Technical Note
BRAIN

Optimizing Dynamic T2* MR Imaging for Measurement of Cerebral Blood Flow Using Infusions for Cerebral Blood Volume

G.C. Newman^a,b, F.E. Hospod^a, S.B. Fain^b,c and T.D. Cook^c

^a Department of Neurology, University of Wisconsin School of Medicine, Madison, Wis
^b Department of Radiology, University of Wisconsin School of Medicine, Madison, Wis
^c Department of Medical Physics, University of Wisconsin School of Medicine, Madison, Wis
^d Department of Biostatistics, University of Wisconsin School of Medicine, Madison, Wis

Address correspondence to George C. Newman, MD, PhD, Department of Neurosensory Sciences, Albert Einstein Medical Center, 5401 Old York Rd, Klein Suite #310, Philadelphia, PA 19141

Summary: We describe an approach to measuring cerebral blood flow (CBF) based on independent measurements of cerebral blood volume (CBV) and mean transit time (MTT) with calculation of CBF by using the central volume theorem: CBF = CBV / MTT. This permits optimization of the individual acquisitions and analyses. In particular, measurement of CBV during contrast infusion, rather than simultaneously with MTT from a single bolus, yields values more consistent with those of other methods.