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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:1312-1314, June-July 2006
© 2006 American Society of Neuroradiology

Case Report
HEAD AND NECK

Diffusion-Weighted Cranial MR Imaging Findings in a Patient with Hemophagocytic Syndrome

B. Ozgen^a, K. Karli-Oguz^a, B. Sarikaya^a, B. Tavil^b and A. Gurgey^b

^a Departments of Radiology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
^b Pediatric Hematology, Hacettepe University, Faculty of Medicine, Ankara, Turkey

Address correspondence to Burce Ozgen, MD, Department of Radiology, Hacettepe University, Faculty of Medicine, Sihhiye, Ankara 06100 Turkey

SUMMARY: Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of the immune system that is associated with frequent involvement of the central nervous system (CNS). The MR imaging and CT findings of the CNS infiltration have been reported in the past; however, the diffusion-weighted imaging (DWI) findings have not been previously described. We present MR imaging findings in a case of secondary HLH with CNS involvement, with an emphasis on the DWI findings.