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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:1447-1449, August 2006
© 2006 American Society of Neuroradiology

Case Report
BRAIN

Multiple Reversible MR Signal Changes Caused by Epstein-Barr Virus Encephalitis

G. Hagemann^a, H.-J. Mentzel^b, H. Weisser^c, A. Kunze^a and C. Terborg^a

^a Department of Neurology, Friedrich-Schiller-University, Jena, Germany
^b Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University, Jena, Germany
^c Institute of Medical Microbiology, Friedrich-Schiller-University, Jena, Germany

Address correspondence to Georg Hagemann, MD, Department of Neurology, Friedrich-Schiller-University, Erlanger Allee 101, 07740 Jena, Germany; e-mail: hagemann{at}med.uni-jena.de

SUMMARY: This report presents the imaging findings of an unusual case of Epstein-Barr virus (EBV) encephalitis. A young man presented with a short-lasting history of febrile infection, neuropsychologic deficits, ataxia, and seizures. MR imaging revealed fully reversible signal intensities (T2, diffusion-weighted imaging with a decreased apparent diffusion coefficient) in the splenium of the corpus callosum and both posterior hemispheres. EBV infection must be added to the list of differential diagnoses of (reversible) splenial lesions.

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