American Journal of Neuroradiology 27:1703-1709, September 2006
© 2006 American Society of Neuroradiology
INTERVENTIONAL
Computational Fluid Dynamics Modeling of Intracranial Aneurysms: Effects of Parent Artery Segmentation on Intra-Aneurysmal Hemodynamics
a School of Computational Sciences, George Mason University, Fairfax, Va
b Department of Interventional Neuroradiology, Inova Fairfax Hospital, Fairfax Radiological Consultants, Falls Church, Va
c Department of Neurosurgery, George Washington University School of Medicine, Washington, DC
Address correspondence to Christopher M. Putman, MD, Interventional Neuroradiology, Inova Fairfax Hospital, 3300 Gallows Rd, Falls Church, VA 22042; e-mail: christopher.putman{at}inova.com
PURPOSE: The purpose of this study is to show the influence of the upstream parent artery geometry on intraaneurysmal hemodynamics of cerebral aneurysms.
METHODS: Patient-specific models of 4 cerebral aneurysms (1 posterior communicating artery [PcomA], 2 middle cerebral artery [MCA], and 1 anterior communicating artery [AcomA]) were constructed from 3D rotational angiography images. Two geometric models were constructed for each aneurysm. One model had the native parent vessel geometry; the second model was truncated approximately 1 cm upstream from the aneurysm, and the parent artery replaced with a straight cylinder. Corresponding finite element grids were generated and computational fluid dynamics simulations were carried out under pulsatile flow conditions. The intra-aneurysmal flow patterns and wall shear stress (WSS) distributions were visualized and compared.
RESULTS: Models using the truncated parent vessel underestimated the WSS in the aneurysms in all cases and shifted the impaction zone to the neck compared with the native geometry. These effects were more pronounced in the PcomA and AcomA aneurysms where upstream curvature was substantial. The MCA aneurysm with a long M1 segment was the least effected. The more laminar flow pattern within the parent vessel in truncated models resulted in a less complex intra-aneurysmal flow patterns with fewer vortices and less velocity at the dome.
CONCLUSIONS: Failure to properly model the inflow stream contributed by the upstream parent artery can significantly influence the results of intra-aneurysmal hemodynamic models. The upstream portion of the parent vessel of cerebral aneurysms should be included to accurately represent the intra-aneurysmal hemodynamics.
This article has been cited by other articles:
 |
|
 |
|
  H. Baek, M. V. Jayaraman, P. D. Richardson, and G. E. Karniadakis Flow instability and wall shear stress variation in intracranial aneurysms J R Soc Interface, December 18, 2009; (2009) rsif.2009.0476v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Chien, M.A. Castro, S. Tateshima, J. Sayre, J. Cebral, and F. Vinuela Quantitative Hemodynamic Analysis of Brain Aneurysms at Different Locations AJNR Am. J. Neuroradiol., September 1, 2009; 30(8): 1507 - 1512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.A. Castro, C.M. Putman, M.J. Sheridan, and J.R. Cebral Hemodynamic Patterns of Anterior Communicating Artery Aneurysms: A Possible Association with Rupture AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 297 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Isaksen, Y. Bazilevs, T. Kvamsdal, Y. Zhang, J. H. Kaspersen, K. Waterloo, B. Romner, and T. Ingebrigtsen Determination of Wall Tension in Cerebral Artery Aneurysms by Numerical Simulation Stroke, December 1, 2008; 39(12): 3172 - 3178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Boussel, V. Rayz, C. McCulloch, A. Martin, G. Acevedo-Bolton, M. Lawton, R. Higashida, W. S. Smith, W. L. Young, and D. Saloner Aneurysm Growth Occurs at Region of Low Wall Shear Stress: Patient-Specific Correlation of Hemodynamics and Growth in a Longitudinal Study Stroke, November 1, 2008; 39(11): 2997 - 3002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ohta, Chuan He, T. Nakayama, A. Takahashi, and D. A. Rufenacht Three-Dimensional Reconstruction of a Cerebral Stent using Micro-CT for Computational Simulation Journal of Intelligent Material Systems and Structures, March 1, 2008; 19(3): 313 - 318. [Abstract] [PDF]
|
|
|
|
|
|
M. S. Alnaes, J. Isaksen, K.-A. Mardal, B. Romner, M. K. Morgan, and T. Ingebrigtsen Computation of Hemodynamics in the Circle of Willis Stroke, September 1, 2007; 38(9): 2500 - 2505. [Abstract] [Full Text] [PDF]
|
|