AJDRAJNR - American Journal of Neuroradiology

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shaibani, A.
Right arrow Articles by Carroll, T.J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shaibani, A.
Right arrow Articles by Carroll, T.J.

American Journal of Neuroradiology 27:1788-1793, September 2006
© 2006 American Society of Neuroradiology

BRAIN

First Results in an MR Imaging-Compatible Canine Model of Acute Stroke

A. Shaibania, S. Khawara, W. Shinb, T.A. Cashenb, B. Schirfa, M. Rohanya, S. Kakodkara and T.J. Carrolla,b

a Department of Radiology, Northwestern University, Chicago, Ill
b Department of Biomedical Engineering, Northwestern University, Chicago, Ill

Address correspondence to Timothy J. Carroll, PhD, Northwestern University, Department of Radiology, 676 N St. Clair, Suite 1400, Chicago, IL 60611; e-mail: t-carroll{at}northwestern.edu

BACKGROUND AND PURPOSE: The purpose of this work was to develop an MR imaging-compatible animal model of reversible embolic stroke. We hypothesize that real-time MR imaging of the brain can be performed during stroke thrombolysis and can provide real-time feedback and guidance on the success of thrombolysis.

METHODS: Embolic strokes were induced in 5 adult dogs by the use of autologous blood clots, with a sixth dog serving as an experimental control. Serial MR anatomic and physiologic imaging was performed to track the evolution of the stroke. The apparent diffusion coefficient (ADC) and quantitative cerebral blood flow (qCBF) were compared in the normal and stroke regions. During and after the administration of a chemical thrombolytic agent, MR imaging was performed to assess the outcome of the treatment.

RESULTS: Strokes were successfully created in 5 animals. No ADC or qCBF changes were observed in the control animal. Both ADC and qCBF values were found to be significantly different in the region affected by the stroke. Restoration of flow was observed in 1 case.

CONCLUSION: We have successfully implemented an MR imaging-compatible canine model of reversible embolic stroke.






Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X