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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 27:1987-1989, October 2006
© 2006 American Society of Neuroradiology

Technical Note
BRAIN

Higher Prevalence of Cortical Lesions Observed in Patients with Acute Stroke Using High-Resolution Diffusion-Weighted Imaging

K. Benameur^a, J.L. Bykowski^a, M. Luby^a, S. Warach^a and L.L. Latour^a

^a From the Section on Stroke Diagnostics and Therapeutics, National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md

Address correspondence to Lawrence L. Latour, Section on Stroke Diagnostics and Therapeutics, NINDS, NIH, 10 Center Dr, Room B1D733, Bethesda, MD 20892-1063; e-mail: latourl{at}ninds.nih.gov

SUMMARY: Ischemic lesion conspicuity on routine diffusion-weighted imaging (DWI, 30 seconds) was compared with an improved sequence (high-resolution DWI [DWI-HR], 256 seconds) having increased spatial resolution and signal to noise and decreased eddy current artifact in 42 patients with acute ischemic stroke. Total lesion volumes were similar; however, twice as many lesions were identified on DWI-HR, predominately in cortical gray matter. Modest improvements to imaging resulted in increased conspicuity, potentially affecting diagnosis, suspected pathogenic mechanism, and therapeutic decision.

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