Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zaharchuk, G. Search for Related Content PubMed PubMed Citation Articles by Zaharchuk, G.

American Journal of Neuroradiology 28:1850-1858, November-December 2007
© 2007 American Society of Neuroradiology

Physics Review

Theoretical Basis of Hemodynamic MR Imaging Techniques to Measure Cerebral Blood Volume, Cerebral Blood Flow, and Permeability

G. Zaharchuk^a

^a From the Neuroradiology Section, Stanford University Medical Center, Stanford, Calif

Please address correspondence to Greg Zaharchuk, PhD, MD, Assistant Professor of Radiology, Neuroradiology Section, Stanford University Medical Center, 1201 Welch Rd, PS-04, Stanford, CA 94305-5487; e-mail: gregz{at}stanford.edu

SUMMARY: Cerebrovascular hemodynamic assessment adds new information to standard anatomic MR imaging and improves patient care. This article reviews the theoretic underpinnings of several potentially quantitative MR imaging–based methods that shed light on the hemodynamic status of the brain, including cerebral blood flow (CBF), cerebral blood volume (CBV), and contrast agent permeability. Techniques addressed include dynamic susceptibility contrast (which most simply and accurately estimates CBV), arterial spin labeling (a powerful method to measure CBF), and contrast-enhanced methods to derive permeability parameters such as the transport constant K_trans.

This article has been cited by other articles:

				W. A. Copen, L. Rezai Gharai, E. R. Barak, L. H. Schwamm, O. Wu, S. Kamalian, R. G. Gonzalez, and P. W. Schaefer Existence of the Diffusion-Perfusion Mismatch within 24 Hours after Onset of Acute Stroke: Dependence on Proximal Arterial Occlusion Radiology, March 1, 2009; 250(3): 878 - 886. [Abstract] [Full Text] [PDF]