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AJNR - American Journal of Neuroradiology

Published ahead of print on September 28, 2007
doi: 10.3174/ajnr.A0695

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American Journal of Neuroradiology 28:2005-2007, November-December 2007
© 2007 American Society of Neuroradiology

Case Report
BRAIN

Relatively Decreased ¹¹C-Methionine Uptake within the Anaplastic Component of a Mixed-Grade Oligodendroglioma

K. Miwa^a, J. Shinoda^a, H. Yano^b and T. Iwama^b

^a Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Department of Neurosurgery, Kizawa Memorial Hospital, Gifu, Japan
^b Department of Neurosurgery, Graduate School of Medicine, Gifu University, Gifu, Japan

Please address correspondence to Kazuhiro Miwa, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, 630 Shimokobi, Kobi-cho, Minokamo 505-0034, Japan; e-mail: doctor.3{at}jasmine.ocn.ne.jp

SUMMARY: A 56-year-old woman presented with a mixed-grade oligodendroglioma. On ¹¹C-methionine [MET]-positron-emission tomography images, heterogeneous uptake of MET was demonstrated in the mass lesion. The part of the lesion with higher MET uptake was identified as an ordinary oligodendroglioma, whereas the part of the lesion with lower MET uptake was an anaplastic component of oligodendroglioma. With oligodendrogliomas, we should be aware of the possibility that MET uptake decreases paradoxically with an increased anaplastic component of oligodendroglioma cells.