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American Journal of Neuroradiology 28:262-266, February 2007
© 2007 American Society of Neuroradiology

BRAIN

Cerebral Cortical Lesions in Multiple Sclerosis Detected by MR Imaging at 8 Tesla

A. Kangarlua, E.C. Bourekasa,c, A. Ray-Chaudhuryb and K.W. Rammohanc

a Department of Radiology, The Ohio State University College of Medicine, Columbus, Ohio
b Department of Pathology, The Ohio State University College of Medicine, Columbus, Ohio
c Department of Neurology, The Ohio State University College of Medicine, Columbus, Ohio

Address correspondence to Kottil W. Rammohan, MD, The Ohio State University Medical Center, Department of Neurology, 449 Means Hall, 1654 Upham Dr, Columbus, Ohio 43210; e-mail: kottil.rammohan{at}osumc.edu

BACKGROUND AND PURPOSE: Conventional imaging of ex-vivo brain at 1.5T in multiple sclerosis (MS) detects only a small fraction of the gray matter cerebral cortical lesions that can be detected by pathology. Our purpose was to examine if imaging at 8T can detect plaques in cortical gray matter (CGM) not evident at 1.5T.

METHODS: An ex-vivo brain obtained at autopsy from a patient with MS was formalin fixed and 1 cm coronal slices were examined using MR imaging at 8T.

RESULTS: Numerous cerebral cortical lesions not evident at 1.5T were seen at 8T. Lesions were easily identified using gradient-echo and spin-echo (SE) as well as diffusion images. MR imaging at 8T identified many of the types of plaques previously evident only by pathology. The magnitude of the cortical involvement in this 1 patient was severe. Lesions in the gray matter readily visible by high-field MR imaging were sometimes barely visible by pathology. MR imaging at 8T often facilitated the detection of such plaques by pathology.

CONCLUSION: This study establishes the utility of high-field imaging at 8T in the delineation of plaques in the cerebral CGM in MS.




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Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X