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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 28:316-317, February 2007
© 2007 American Society of Neuroradiology

Case Report
BRAIN

Imaging Cerebral Amyloid Angiopathy with Susceptibility-Weighted Imaging

E.M. Haacke^a, Z.S. DelProposto^b, S. Chaturvedi^c, V. Sehgal^b, M. Tenzer^e, J. Neelavalli^d and D. Kido^f

^a Institute for Biomedical Research, Detroit, Mich
^b Department of Radiology, Wayne State University, Detroit, Mich
^c Department of Neurology, Wayne State University, Detroit, Mich
^d Department of Biomedical Engineering, Wayne State University, Detroit, Mich
^e School of Medicine, Wayne State University, Detroit, Mich
^f Loma Linda University, Loma Linda, Calif

Address correspondence to E. Mark Haacke, PhD, 440 East Ferry St, Detroit, MI 48202; e-mail: nmrimaging{at}aol.com

SUMMARY: Gradient-echo (GE) imaging is recognized as a means to detect hemorrhagic changes in cerebral amyloid angiopathy (CAA). However, almost 25% of patients with CAA do not show microhemorrhages on T2* GE imaging. We applied a new imaging method, susceptibility weighted imaging (SWI), to evaluate the presence of microhemorrhages. In a suspected case of CAA, where cognitive effects are also present, we show that SWI is much more sensitive in detecting microhemorrhages than conventional methods.