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American Journal of Neuroradiology 28:318-320, February 2007
© 2007 American Society of Neuroradiology

Case Report
BRAIN

Richter Transformation of Chronic Lymphocytic Leukemia Presenting as a Dural-Based Non-Hodgkin Lymphoma Mass

M. Ghofrania, B. Tantiwongkosia, A.S. Smitha and D.A. Wasdahla

a From the Department of Radiology, Aultman Hospital, Canton, Ohio

Please address correspondence to Mohsen Ghofrani, MD, Northeast Ohio Universities College of Medicine, Aultman Hospital, Department of Radiology, 2600 6th St SW, Canton, OH 44710; e-mail: mohsen_48{at}yahoo.com

SUMMARY: Richter transformation is defined as a diffuse large cell lymphoma, occurring by transformation of chronic lymphocytic leukemia (CLL). We present a 64-year-old man with a history of CLL and a left parieto-occipital transtentorial extra-axial mass. The patient underwent CT and MR imaging, demonstrating a large dural-based mass with extracranial extension, which occluded the left transverse sinus. Biopsy of the mass proved a pathologic diagnosis of diffuse large cell non-Hodgkin lymphoma, consistent with Richter transformation of CLL.






Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X