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American Journal of Neuroradiology 28:406-410, March 2007
© 2007 American Society of Neuroradiology

Pathology Review

Neuropathology for the Neuroradiologist: Fluorescence in Situ Hybridization

F.J. Wippold, IIa,b,c and A. Perryd

a Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Mo
b Department of Radiology, Barnes-Jewish Hospital South, St. Louis, Mo
c Department of Radiology/Nuclear Medicine, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md
d Neuropathology Division, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Mo

Please address correspondence to Franz J. Wippold II, MD, Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University Medical Center, 510 South Kingshighway Blvd, St. Louis, MO 63110; e-mail: wippoldf{at}wustl.edu

SUMMARY: Fluorescence in situ hybridization is a molecular cytogenetic technique that localizes segments of DNA within tumor cells by using dyes that are visible with a fluorescent microscope. The technique has proved useful in typing a variety of tumors such as oligodendrogliomas and in understanding the genetic forces driving oncogenesis.






Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X