Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wang, J. Articles by Wang, Y. Search for Related Content PubMed PubMed Citation Articles by Wang, J. Articles by Wang, Y.

American Journal of Neuroradiology 28:543-547, March 2007
© 2007 American Society of Neuroradiology

PEDIATRICS

Characterizing Anatomic Differences in Boys with Attention-Deficit/Hyperactivity Disorder with the Use of Deformation-Based Morphometry

J. Wang^a, T. Jiang^a, Q. Cao^b and Y. Wang^b

^a National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China
^b Institute of Mental Health, Peking University, Beijing People's Republic of China

Address correspondence to Tianzi Jiang, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, People's Republic of China; e-mail: jiangtz{at}nlpr.ia.ac.cn

BACKGROUND AND PURPOSE: Most previous neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) rely on the manual delineation of the region of interest, which is subjective and lacks reproducibility. The purpose of this study was to use an automated method to assess whether there are abnormalities in the brains of patients with ADHD. In view of findings from previous imaging and neuropsychologic studies, we predicted that we would detect abnormalities in many brain regions of patients with ADHD.

MATERIALS AND METHODS: Twelve boys with ADHD and 12 control subjects underwent MR imaging assessments. Statistically significant changes in regional volume were analyzed by using deformation based morphometry (DBM). This technique derived a voxel-wise estimation of regional tissue volume change from the deformation field required to warp subject to the template image. Morphologic differences between groups were estimated at each voxel, applying a threshold (P < .001) to the resulting voxel statistic maps to generate clusters of spatially contiguous suprathreshold voxels,

RESULTS: The statistical results reveal some pronounced volume alterations in the brains of ADHD. Volume reductions are mainly localized in right prefrontal (Talairach 48, 20, 31), right medial temporal (Talairach 59, –52, 13), left parietal lobe (Talairach –32, –61, 41), and right basal ganglia (especially right putamen) (Talairach 21, 1, 11); the regions of volume enlargement in the brains of ADHD are observed in the right occipital lobe (Talairach 20, –86, 29) and in the left posterior lateral ventricle (Talairach –23, –40, 15).

CONCLUSION: Our findings confirm that there are widespread abnormalities in volume of boys with ADHD.

This article has been cited by other articles:

				S. Brar, D. Henderson, J. Schenck, and E. A. Zimmerman Iron Accumulation in the Substantia Nigra of Patients With Alzheimer Disease and Parkinsonism Arch Neurol, March 1, 2009; 66(3): 371 - 374. [Abstract] [Full Text] [PDF]