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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 28:567-569, March 2007
© 2007 American Society of Neuroradiology

SPINE

Effect on Partial Pressure of Oxygen in Arterial Blood in Percutaneous Vertebroplasty

A. Uemura^a, Y. Numaguchi^a, M. Matsusako^a, N. Kobayashi^a, Y. Saida^a and M. Rahman^b

^a Department of Radiology, St. Luke's International Hospital, Tokyo, Japan
^b Department of Clinical Practice Evaluation and Research, St. Luke's International Hospital, Tokyo, Japan

Address correspondence to Akihiro Uemura, MD, Department of Radiology, St. Luke's International Hospital, Akashi-cho 9-1, Chuo-ku, Tokyo, 104-8560 Japan; e-mail: akuemura{at}luke.or.jp

BACKGROUND AND PURPOSE: The purpose of this study is to estimate the change in partial pressure of oxygen (PaO₂) during percutaneous vertebroplasty and also to examine the factors related to the change in PaO₂.

MATERIALS AND METHODS: We retrospectively reviewed preprocedural and postprocedural PaO₂ of 59 consecutive patients who underwent percutaneous vertebroplasty between November 2003 and April 2005 (11 men and 48 women; age range, 50–93; mean age, 75 years). Fifty-four patients were treated for osteoporosis-related fractures and 5 had malignant disease. Percutaneous vertebroplasty was performed in a conventional manner under local anesthetics and conscious sedation. Preprocedural and postprocedural blood drawing was performed 5 days to 30 minutes before percutaneous vertebroplasty and also at 30 minutes after the injection of bone cement. The difference between preprocedural and postprocedural data of PaO₂ was correlated with patients’ age, number of treated vertebral bodies, presence of cement leakage, and presence of malignant neoplasm for each patient.

RESULTS: Mean pre-PaO₂ and post-PaO₂ were 80.9 ± 1.4 and 70.6 ± 1.3 mm Hg (mean ± SE) respectively (P = .0001). Using analysis of variance, there was a significant difference according to the number of vertebral bodies. There was a positive trend of decrease in PaO₂ according to the number of vertebral bodies during percutaneous vertebroplasty. Using multiple linear regression and after adjusting by preprocedural PaO₂ and other variables, the number of vertebral bodies was still highly significant.

CONCLUSION: PaO₂ decreases during percutaneous vertebroplasty, and there is a correlation between the number of treated vertebral bodies and decrease in PaO₂.

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