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American Journal of Neuroradiology 28:640-644, April 2007
© 2007 American Society of Neuroradiology

INTERVENTIONAL

Cerebral Hemodynamic Changes after Carotid Angioplasty and Stenting

M.B. Sánchez-Arjonaa, G. Sanz-Fernándezb, E. Franco-Macíasa and A. Gil-Peraltaa

a Neurology and Neurophysiology Department, University Hospital Virgen del Rocío, Seville, Spain
b Neurology Department, Hospital Juan Ramón Jiménez, Huelva, Spain

Address correspondence to María Bernal Sánchez-Arjona, Neurology and Neurophysiology Department, 1st floor HRT, University Hospital Virgen del Rocío, Av Manuel Siurot sn, 41013 Seville, Spain; e-mail: mbs-a{at}ole.com

BACKGROUND AND PURPOSE: Carotid angioplasty stent placement (CAS) is an accepted alternative to endarterectomy. However, little is known about its effect on cerebral hemodynamics. We prospectively studied the early and delayed hemodynamic changes after CAS.

ATERIALS AND METHODS: Sixty patients underwent CAS for ≥70% internal carotid artery stenosis. Transcranial Doppler (TCD) was done before, 6 hours, and 30 days after CAS. Cerebrovascular reserve to apnea (CVR) was measured.

RESULTS: On the ipsilateral side, basal middle cerebral artery (MCA) middle flow velocity (MFV) and pulsatility index (PI) increased from 49.7 cm/s and 0.85, respectively, to 62.5 cm/s and 1.09 immediately after CAS (P < .05); anterior cerebral artery (ACA) MFV and PI increased from 50.7 cm/s and 0.90, to 58.9 cm/s and 1.08 (P < .05); and posterior cerebral artery (PCA) MFV decreased from 47.5 to 36.5 cm/s, with no change in PI (P < .05). On the contralateral side, nonsignificant changes were seen on MCA, immediately after CAS; ACA and PCA MFV decreased from 63.7 and 45.3 cm/s to 50.3 and 38.6 cm/s, respectively (P < .05); ACA and PCA PI increased from 0.96 and 1.00, respectively, to 1.04 and 1.04 (P < .05). At 30 days, ipsilateral MCA MFV and PI were 52.8 cm/s and 1.12, respectively (P < .05), and contralateral values were 49.6 cm/s (P < .05) and 1.02 (nonsignificant), respectively. Basal ipsilateral and contralateral CVR improved from 26.0% to 37.0% (P < .05), and from 30.1% to 33.5% (nonsignificant), respectively, at 30 days.

CONCLUSIONS: CAS produces an early significant increase of MFV and PI in the ipsilateral anterior circulation. This effect is maintained, though minor, 30 days later. In addition, CAS results in an improvement of CVR at 30 days.




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