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American Journal of Neuroradiology 28:971-973, May 2007
© 2007 American Society of Neuroradiology

Case Report
HEAD & NECK

Idiopathic Hypereosinophilic Syndrome with Skull Base Involvement

M.L. Battinenia, S.L. Galettac, J. Oha, M. Langof, J.J. Brookse, S.J. Schusterb and L.A. Loevnera,d

a Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa
b Department of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pa
c Department of Neurology and Opthalmology, Hospital of the University of Pennsylvania, Philadelphia, Pa
d Department of Otorhinolaryngology, Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pa
e Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pa
f Department of Head and Neck Surgery, Fox Chase Cancer Center, Philadelphia, Pa

Please address correspondence to Laurie A. Loevner, MD, Department of Radiology, 3400 Spruce St, Philadelphia, PA 19104; e-mail: laurie.loevner{at}uphs.upenn.edu

SUMMARY: Idiopathic hypereosinophilic syndrome (HES) is a heterogeneous disorder characterized by prolonged eosinophilia without an identifiable cause, ultimately resulting in organ dysfunction. Three major types of neurologic involvement have been well defined in HES; however, to our knowledge, inflammatory pseudotumor (IPT) in association with HES has not been reported. We present a case of IPT of the skull base in a patient with HES that suggests that HES may result in an exaggerated immunologic or inflammatory response leading to the formation of IPT.






Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X