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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 28:1093-1094, June-July 2007
DOI 10.3174/ajnr.A0527
© 2007 American Society of Neuroradiology

Technical Note
BRAIN

Improved Visibility of the Subthalamic Nucleus on High-Resolution Stereotactic MR Imaging by Added Susceptibility (T2*) Contrast Using Multiple Gradient Echoes

E. Elolf^a, V. Bockermann^b, T. Gringel^a,c, M. Knauth^a, P. Dechent^c and G. Helms^c

^a Department of Neuroradiology, Georg-August-Universität Göttingen, Göttingen, Germany
^b Department of Neurosurgery, Georg-August-Universität Göttingen, Göttingen, Germany
^c MR-Research in Neurology and Psychiatry, Georg-August-Universität Göttingen, Göttingen, Germany

Address correspondence to Gunther Helms, MR-Forschung in der Neurologie und Psychiatrie, Universitätsklinikum, D-37099 Göttingen, Germany; e-mail: ghelms{at}gwdg.de

SUMMARY: Reliable identification of the subthalamic nucleus (STN) is a critical step in deep brain stimulation for Parkinson disease but difficult on T1-weighted stereotactic MR imaging. By simultaneous imaging of multiple gradient echoes, susceptibility contrast is added to conventional T1-weighted high-resolution MR image. Thus, the visibility of the STN is enhanced on a second co-localized dataset by exploiting the sensitivity of the T2*-relaxation to local iron deposits. The feasibility is underpinned by quantitative measurements on healthy adults.

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