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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 28:1176-1178, June-July 2007
DOI 10.3174/ajnr.A0507
© 2007 American Society of Neuroradiology

Case Report
INTERVENTIONAL

Bone Formation in Elastase-Induced Rabbit Aneurysms Embolized with Platinum Coils: Report of 2 Cases

D. Dai^a, Y.H. Ding^a, R. Kadirvel^a, D.A. Lewis^a, H.J. Cloft^a and D.F. Kallmes^a

^a From the Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minn

Address correspondence to David F. Kallmes, Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: kallmes.david{at}mayo.edu

SUMMARY: Histologic findings in 71 elastase-induced rabbit aneurysms embolized with platinum coils were retrospectively reviewed. Mature bone formation was found in 2 aneurysms, one with coils implanted for 3 months and the other with coils implanted for 1 year. We present the histologic findings and offer potential explanations for these observations. These findings may be relevant in understanding mechanisms of aneurysm healing after coil embolization.

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