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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 28:1486-1488, September 2007
DOI 10.3174/ajnr.A0596
© 2007 American Society of Neuroradiology

Case Report
BRAIN

Magnetoencephalographic Mapping of Interictal Spike Propagation: A Technical and Clinical Report

K. Hara^a, F.-H. Lin^a,b, S. Camposano^a, D.M. Foxe^a, P.E. Grant^a, B.F. Bourgeois^c, S.P. Ahlfors^a and S.M. Stufflebeam^a

^a From MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Mass
^b Institute of Biomedical Engineering, National Taiwan University, Taipei, Republic of China
^c Division of Epilepsy and Clinical Neurophysiology, Children's Hospital, Boston, Mass

Please address correspondence to Fa-Hsuan Lin, PhD, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Rm 2301, Charlestown, MA 02129; e-mail: fhlin@nmr.mgh.harvard.edu; or Institute of Biomedical Engineering, National Taiwan University, #1, Section 1, Jen-Ai Rd, Taipei 100, Republic of China; e-mail: fhlin{at}ntu.edu.tw

SUMMARY: Distinguishing propagated epileptic activity from primary epileptic foci is of critical importance in presurgical evaluation of patients with medically intractable focal epilepsy. We studied an 11-year-old patient with complex partial epilepsy by using simultaneous magnetoencephalography (MEG) and electroencephalography (EEG). In EEG, bilateral interictal discharges appeared synchronous, whereas MEG source analysis suggested propagation of spikes from the right to the left frontal lobe.

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