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American Journal of Neuroradiology 28:1499-1500, September 2007
DOI 10.3174/ajnr.A0611
© 2007 American Society of Neuroradiology

Case Report
BRAIN

Decrease in the Volume of White Matter Lesions with Improvement of Hepatic Encephalopathy

B. Míngueza,b, A. Rovirac, J. Alonsob,c and J. Córdobaa,b

a From the Servicio de Medicina Interna-Hepatología, Hospital Universitario Valle Hebron, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona Spain
b Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Hospital Universitario Valle Hebron, Barcelona, Spain
c Unidad de Resonancia Magnética, Servicio de Radiología, Hospital Universitario Valle Hebron, Barcelona, Spain

Please address correspondence to Juan Córdoba, Servicio de Medicina Interna-Hepatología, Hospital Universitario Valle Hebrón, Paseo Valle Hebrón 119, Barcelona 08035, Spain; e-mail: jcordoba{at}vhebron.net

SUMMARY: MR imaging has found abnormalities compatible with low-grade edema in the brain of patients with cirrhosis that have been related to hepatic encephalopathy. We present 3 patients with hepatic encephalopathy who exhibit supratentorial focal or diffuse white matter lesions compatible with small-vessel brain disease. The volume and number of white matter lesions reduced with the improvement of hepatic encephalopathy, suggesting the participation of the blood-brain barrier in the pathogenesis of brain edema in hepatic encephalopathy.




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A. Rovira, J. Alonso, and J. Cordoba
MR Imaging Findings in Hepatic Encephalopathy
AJNR Am. J. Neuroradiol., October 1, 2008; 29(9): 1612 - 1621.
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Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X