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AJNR - American Journal of Neuroradiology

Published ahead of print on September 24, 2007
doi: 10.3174/ajnr.A0712

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American Journal of Neuroradiology 28:1650-1651, October 2007
© 2007 American Society of Neuroradiology

Technical Note
BRAIN

Serial Whole-Brain N-Acetylaspartate Concentration in Healthy Young Adults

D.J. Rigotti^a, M. Inglese^a, J.S. Babb^a, M. Rovaris^b, B. Benedetti^b, M. Filippi^b, R.I. Grossman^a and O. Gonen^a

^a Department of Radiology, New York University School of Medicine, New York, NY
^b Neuroimaging Research Unit, Department Neurology, Scientific Institute and University, San Raffaele Hospital, Milan, Italy

Please address correspondence to Oded Gonen, Department of Radiology, New York University School of Medicine, 650 First Ave, 6th Floor, New York, NY 10016; e-mail: oded.gonen{at}med.nyu.edu

SUMMARY: Although the concentration of N-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over the 1–2 year periods of typical clinical trials, the whole-brain NAA concentration was measured longitudinally, over 4 years, in a cohort of healthy young adults. No significant change (adjusted for both sex and age) was measured either interpersonally or intrapersonally over the entire duration of the study.

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