doi: 10.3174/ajnr.A0748
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
American Journal of Neuroradiology 29:154-158, January 2008
© 2008 American Society of Neuroradiology
BRAIN
Susceptibility-Weighted Imaging for the Evaluation of Patients with Familial Cerebral Cavernous Malformations: A Comparison with T2-Weighted Fast Spin-Echo and Gradient-Echo Sequences
a Divisions of Neurosurgery, Department of Radiology, University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
b Department of Surgery and Division of Neuroradiology, Department of Radiology, University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
c Multi-Imagem, Rio de Janeiro, RJ, Brazil
d CDPI-Clínica de Diagnóstico Por Imagem, Rio de Janeiro, RJ, Brazil
Please address correspondence to Jorge Marcondes de Souza, MD, PhD, Hospital Universitário Clementino Fraga Filho, Rua Professor Rodolpho Paulo Rocco 255, Cidade Universitária-Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, Brazil; e-mail: jmarcondes{at}hucff.ufrj.br
BACKGROUND AND PURPOSE: The T2-weighted gradient-echo (GRE) imaging is currently the gold standard MR imaging sequence for the evaluation of patients with cerebral cavernous malformation (CCM) lesions. We aimed to compare the sensitivity of susceptibility-weighted imaging (SWI) with T2-weighted fast spin-echo (FSE) and GRE imaging in assigning the number of CCM lesions in patients with the familial form of the disease.
Materials and METHODS: We studied 15 patients (8 men, 7 women; mean age, 34 years) with familial CCM. All patients underwent MR imaging with the following sequences: T1-weighted spin echo, T2-weighted FSE, T2-weighted GRE, and SWI. Two neuroradiologists read the images regarding the number of lesions seen on each sequence. The final decisions were reached by consensus. The number of lesions on the different sequences was compared with analysis of variance, followed by a nonparametric Wilcoxon matched-pairs signed rank test.
RESULTS: The number of lesions was higher on T2-weighted GRE than on T2-weighted FSE (P = .001). In addition, more lesions were seen on SWI than on T2-weighted GRE (P = .001) and FSE (P = .001) sequences.
CONCLUSION: The sensitivity of SWI in assigning the number of CCM lesions in patients with the familial form of the disease is significantly higher than that of T2-weighted FSE and GRE sequences.
This article has been cited by other articles:
 |
|
 |
|
  J.A. Palma, J.L. Zubieta, P.D. Dominguez, and R. Garcia-Eulate Pneumocephalus Mimicking Cerebral Cavernous Malformations in MR Susceptibility-Weighted Imaging AJNR Am. J. Neuroradiol., June 1, 2009; 30(6): e83 - e83. [Full Text] [PDF]
|
|
|
|
|
|
Prof. E.L. Gasparetto, F. Nirenberg, and Prof. J. M. de Souza Reply: AJNR Am. J. Neuroradiol., June 1, 2009; 30(6): e84 - e84. [Full Text] [PDF]
|
|
|
|
|
|
R.N.K. Nandigam, A. Viswanathan, P. Delgado, M.E. Skehan, E.E. Smith, J. Rosand, S.M. Greenberg, and B.C. Dickerson MR Imaging Detection of Cerebral Microbleeds: Effect of Susceptibility-Weighted Imaging, Section Thickness, and Field Strength AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 338 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mittal, Z. Wu, J. Neelavalli, and E.M. Haacke Susceptibility-Weighted Imaging: Technical Aspects and Clinical Applications, Part 2 AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 232 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.M. Haacke, S. Mittal, Z. Wu, J. Neelavalli, and Y.-C.N. Cheng Susceptibility-Weighted Imaging: Technical Aspects and Clinical Applications, Part 1 AJNR Am. J. Neuroradiol., January 1, 2009; 30(1): 19 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Al-Shahi Salman, M. J. Berg, L. Morrison, I. A. Awad, and on behalf of the Angioma Alliance Scientific Advis Hemorrhage From Cavernous Malformations of the Brain: Definition and Reporting Standards Stroke, December 1, 2008; 39(12): 3222 - 3230. [Abstract] [Full Text] [PDF]
|
|